Anticonvulsant drugs commonly used to treat low back pain were found to be ineffective and can have adverse effects, according to a new study. The findings of the study are published in CMAJ (Canadian Medical Association Journal).
‘Anticonvulsant drugs used to treat low back pain, and lumbar radicular pain were found to ineffective and can have adverse effects.’
Low back pain affects millions of people and is the number one cause of disability. Clinical practice guidelines usually recommend nonpharmacologic treatments and nonopioid pain relievers rather than stronger analgesics such as anticonvulsants.
The study findings are based on high and moderate-quality evidence from 9 placebo-controlled randomized trials that found a lack of evidence of benefit from anticonvulsants and more adverse events from some of these drugs.
“We have shown, with mostly high- and moderate-quality evidence, that common anticonvulsants are ineffective for chronic low back pain and lumbar radicular pain, and are accompanied by increased risk of adverse events,” write the authors.
These findings support recent guidelines from the United States and the United Kingdom that do not recommend the use of anticonvulsants.
“Anticonvulsants in the treatment of low back pain and lumbar radicular pain: a systematic review and meta-analysis” was published.